Geometric cues for directing the differentiation of mesenchymal stem cells.

@article{Kilian2010GeometricCF,
  title={Geometric cues for directing the differentiation of mesenchymal stem cells.},
  author={Kristopher A Kilian and Branimir Bugarija and Bruce T. Lahn and Milan Mrksich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 11},
  pages={4872-7}
}
Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to competing soluble differentiation signals, cells cultured in rectangles with increasing aspect ratio and in shapes with pentagonal symmetry but with different subcellular curvature-and… CONTINUE READING
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