Geometric constraints dominate the antigenic evolution of 1 influenza H 3 N 2 hemagglutinin 2

Abstract

11 We have carried out a comprehensive analysis of the determinants of human influenza A H3 12 hemagglutinin evolution, considering three distinct predictors of evolutionary variation at in13 dividual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), 14 experimental epitope sites (as a proxy for host immune bias), and… (More)

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