Geometric and electronic structure/function correlations in non-heme iron enzymes.

  title={Geometric and electronic structure/function correlations in non-heme iron enzymes.},
  author={Edward I. Solomon and Thomas C Brunold and Mindy I. Davis and Jyllian N Kemsley and Sam Keun Lee and Nicole Lehnert and Frank Neese and Andrew J Skulan and Yinshan Yang and Jian Zhou},
  journal={Chemical reviews},
  volume={100 1},
ion step follows the decarboxylation, which is consistent with the deuterium isotopic effects observed for thymine 7-hydroxylase which indicate that an irreversible step (or steps) occurs prior to the C-H bond breaking.395 It has also been shown for prolyl 4-hydroxylase that a substrate-derived radical is generated in the reaction, which is consistent with a rebound mechanism.437 It is important to point out that no oxygen intermediate (i.e., bridged superoxo or oxo-ferryl) has been observed… CONTINUE READING


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