Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand.

@article{Rungsihirunrat2008GeographicalDO,
  title={Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand.},
  author={Kanchana Rungsihirunrat and Carol Hopkins Sibley and Mathirut 5 Mungthin and Kesara Na-Bangchang},
  journal={The American journal of tropical medicine and hygiene},
  year={2008},
  volume={78 3},
  pages={462-7}
}
Both malaria treatment and prophylaxis target the parasite dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes. Specific point mutations in these genes confer resistance to sulfadoxine-pyrimethamine (SP) in both Plasmodium falciparum and P. vivax. We used direct sequencing to examine the prevalence of point mutations in pvdhps and… CONTINUE READING