Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: Systematic review and meta-analysis

  title={Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: Systematic review and meta-analysis},
  author={Kari Juhani Syrj{\"a}nen},
  journal={Scandinavian Journal of Infectious Diseases},
  pages={1 - 18}
  • K. Syrjänen
  • Published 1 January 2013
  • Biology
  • Scandinavian Journal of Infectious Diseases
Abstract Background: Since the first reports in 1982 suggesting an aetiological role for human papillomavirus (HPV) in a subset of oesophageal squamous cell carcinomas (ESCC), the literature reporting HPV detection in ESCC has expanded rapidly. However no formal meta-analysis of this literature has been published yet. The objective of this study was to perform a systematic review and formal meta-analysis of the literature reporting HPV detection in ESCC. Methods: MEDLINE and Current Contents… 
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This meta-analysis of case-control studies investigating the role of HPV in OSCC suggests that HPV increases the risk of OSCC three-fold, providing the strongest evidence to date of an HPV-OSCC association.
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A meta-analysis of human papillomavirus as a risk factor for oesophageal squamous cell carcinoma in China provides the strongest evidence until now of an association between HPV and OSCC in the Chinese population.
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High-risk HPVs were observed in ESCC cases and controls from different regions of Iran, and the odds ratio indicates that the HPV infection in ES CC cases was approximately 2 fold more than the controls.
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HPVs should now be seriously considered as etiological agents for at least a subset of ESCC, and more studies are needed to provide conclusive evidence that HPVs cause ESCC.
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The overall high prevalence of HPV indicates it as a possible risk factor for ESSC in northwest Pakistan which is part of high risk belt for this disease.
Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran
It is indicated that, among a group of Kurdish people in two provinces in the west of Iran, as a low-risk ESCC area, HPV could be one of the risk factors, although in a small proportion of the patients.
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Efforts must be undertaken to standardize HPV testing, ideally in a central laboratory and utilizing tests that detect viral transcriptional activity; avoid cross‐contamination; and recruit large numbers of patients to accurately ascertain HPV rates in esophageal malignancy.
The prevalence of HPV infection is high in esophageal squamous cell carcinoma presenting in almost half of the cases, without gender differentiation, according to histopathological and immunohistochemical analysis by p16.


HPV infections and oesophageal cancer
It may be that the (multifactorial) aetiology of oesophageal cancer differs greatly between those geographical areas with a low risk and those with a high risk for this disease.
Evaluation of the role of human papillomavirus in oesophageal squamous cell carcinoma in Belgium.
The data are in agreement with those previously published, suggesting that HPV infection only plays a minor role in the pathogenesis of oesophageal squamous cells carcinoma in West-European countries.
InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers.
Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, it cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.
Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients
The results are consistent with HPV studies conducted in other high-risk areas for ESCC and provided further evidence to support a causal association of HPV infection with ESCC.
p53 mutations in human papillomavirus-associated oesophageal squamous cell carcinoma.
  • K. Cooper
  • Medicine
    British Journal of Cancer
  • 1995
Both the Finnish (of Chinese patients) and South African studies provide evidence to support the hypothesis that certain HPV genomes are essential but not sufficient for progression to malignancy and that synergistic actions with other carcinogenic agents are necessary.
High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma
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The findings raise the possibility that HPV is involved in esophageal carcinogenesis, especially the non-keratinizing type of SCC, and further investigation with a larger sample size over broader geographic areas may be warranted.
Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus.