Geographic heterogeneity of neoplasia-associated chromosome aberrations.

  title={Geographic heterogeneity of neoplasia-associated chromosome aberrations.},
  author={B H Brusheim Johansson and Fredrik Mertens and Felix Mitelman},
  journal={Genes, chromosomes & cancer},
  volume={3 1},
Using a database comprising 13,266 cytogenetically abnormal neoplasms, the geographic heterogeneity of neoplasia-associated chromosomal abnormalities was investigated by comparing the frequencies of characteristic aberrations in consecutive series of patients with the same diagnosis. Significant frequency differences between geographic areas were found for the aberrations +8, i(17q), +19, and an additional Ph1 chromosome in chronic myeloid leukemia (CML); -5, 5q-, and +8 in acute nonlymphocytic… CONTINUE READING


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