Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer

@article{Anantharaman2017GeographicHI,
  title={Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer},
  author={Devasena Anantharaman and Behnoush Abedi-Ardekani and Daniel C. Beachler and Tarik Gheit and Andrew F. Olshan and Kathy Wisniewski and Victor Wunsch-Filho and Tatiana Natasha Toporcov and Eloiza Helena Tajara and Jos{\'e} Eduardo Levi and Raquel Ajub Moyses and Stefania Boccia and Gabriella Cadoni and Guido Rindi and Wolfgang Ahrens and Franco Merletti and David I Conway and Sylvia Wright and Christine Carreira and H{\'e}l{\`e}ne Renard and Priscilia Chopard and Sandrine Mckay-Chopin and Ghislaine Scelo and Massimo Tommasino and Paul J Brennan and Gypsyamber D’Souza},
  journal={International Journal of Cancer},
  year={2017},
  volume={140}
}
Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and… 
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HPV infection in oropharyngeal squamous cell carcinomas: correlation with tumor size.
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Results showed that survival was adversely effected by the stage of the disease and tumor size and indirectly by the presence of HPV - especially in young adults - while the combined surgery/radiotherapy/ chemotherapy therapy seems to prolong survival.
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TLDR
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