Gentiana asclepiadea protects human cells against oxidation DNA lesions.

  title={Gentiana asclepiadea protects human cells against oxidation DNA lesions.},
  author={Alexandra Hudecov{\'a} and Katar{\'i}na Ha{\vs}plov{\'a} and Eva Miadokov{\'a} and Zuzana Magdol{\'e}nov{\'a} and Alessandra Rinna and Andrew R Collins and Eli{\vs}ka G{\'a}lov{\'a} and Dagmar Vacul{\vc}{\'i}kov{\'a} and Fridrich Greg{\'a}ň and M{\'a}ria Du{\vs}insk{\'a}},
  journal={Cell biochemistry and function},
  volume={30 2},
The objectives of this study were to examine whether the methanolic and aqueous extracts from the haulm and flower of Gentiana asclepiadea exhibited free radical scavenging and protective (antigenotoxic) effect against DNA oxidation induced by H(2)O(2) in human lymphocytes and human embryonic kidney cells (HEK 293). All four extracts exhibited high scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radicals at concentrations 2.5 and 25 mg ml(-1). The level of DNA damage was measured using the… CONTINUE READING


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