Gentamicin tympanoclysis: effects on the vestibular secretory cells.

  title={Gentamicin tympanoclysis: effects on the vestibular secretory cells.},
  author={D J Pender},
  journal={American journal of otolaryngology},
  volume={6 5},
  • D J Pender
  • Published 1985 in American journal of otolaryngology
Gentamicin application to the middle ear may relieve Meniere's disease, presumably by reducing endolymph secretion by the dark cells. To explore this possibility, the ears of adult cats were treated with daily intratympanic infusions of gentamicin until ataxia occurred. The temporal bones of these cats were then examined using electron microscopy. A 3 per cent solution of gentamicin resulted in ataxia after four treatments. Acute dark cell damage to basal infoldings seen after one month… CONTINUE READING

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