Gentamicin-loaded microspheres for treatment of experimental Brucella abortus infection in mice.

@article{Prior2005GentamicinloadedMF,
  title={Gentamicin-loaded microspheres for treatment of experimental Brucella abortus infection in mice.},
  author={Sandra Prior and Bruno A Gander and Juan M Irache and Carlos Gamazo},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 6},
  pages={1032-6}
}
OBJECTIVES To evaluate the efficacy of gentamicin-loaded poly (lactide-co-glycolide) 50:50H (PLGA 50:50H) microspheres for the treatment of mice experimentally infected with Brucella abortus 2308. METHODS The microspheres were dispersed in either 2% (w/v) poloxamer 188 saline solution, or deionized water with the help of a cell homogenizer to break up particle aggregates, and were administered intravenously or intraperitoneally to B. abortus-infected mice 7 days post-infection. RESULTS… CONTINUE READING

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