Gentamicin inhibits carrier-mediated dipeptide transport in kidney.

  title={Gentamicin inhibits carrier-mediated dipeptide transport in kidney.},
  author={Hal A. Skopicki and Demetrios Zikos and Ernest J. Sukowski and K A Fisher and Darryl R. Peterson},
  journal={The American journal of physiology},
  volume={270 3 Pt 2},
The effect of gentamicin on transport of pyroglutamylhistidine (pGlu-His) was examined in rabbit renal brush-border membrane vesicles (BBMV). Gentamicin, an aminoglycoside antibiotic, is limited in its usage because of nephrotoxicity characterized in part by transport defects in the proximal tubule. Since there is no information regarding the effects of gentamicin on renal peptide carriers, uptake of [3H]pGlu-His was measured in BBMV following either in vivo or in vitro exposure to the… 
Increased Apical Insertion of the Multidrug Resistance Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules following Gentamicin Exposure
It is concluded that an increased shuttling of the transporter to the apical membrane takes place in response to gentamicin exposure, which is triggered by endothelin.
An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin.
Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative microorganisms and other effects of gentamicin have also been linked to cell death, such as phospholipidosis, oxidative stress, extracellular calcium-sensing receptor stimulation, and energetic catastrophe.
New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view.
An integrative view on the interactions of tubular, glomerular, and vascular effects of gentamicin is presented, in the context of the most recent information available, for prevention of aminoglycoside nephrotoxicity derived from the pathophysiological knowledge.
Dopamine protects gentamicin early induced nephrotoxicity in Sprague–Dawley rats
It is concluded that renovascular effects of dopamine were early attributed to glomerular preservation, whereas the tubule function prepared by the amino acid was just a consequent of gentamicin-induced nephrotoxicity.
Aminoglycosides: Nephrotoxicity
The present minireview tries to present in a prospective way the status of both the basic and the clinical research on aminoglycoside nephrotoxicity in order to clarify the main issues and to pinpoint strategies that may eventually lead to their safer use.
Prevention of nephrotoxicity requires knowledge of pathogenic mechanisms of renal injury, patient related risk factors, drug-related risk Factors, and pre-emptive measures, coupled with vigilance and early intervention.
Effect of Butanol Extract of Maturated Mahkota Dewa (Phaleria macrocarpa) Fruit on Liver Tissue of Mice (Mus musculus)
The result showed that butanol extract of maturated mahkota dewa fruit with dosage until 85 mg/kg body weight did not affect kidney tissue, but at dosage 170 mg/ kg body weight, a light necrosis on proximal convoluted tubules was occurred.
Identificación de biomarcadores urinarios para la mejora del diagnóstico del daño renal agudo inducido por gentamicina
[ES] La gentamicina antibiotico aminoglucosido ampliamente utilizado en la practica clinica para el tratamiento de infecciones por microorganismos Gram negativos. Sin embargo, su uso esta limitado