Gentamicin inhibits carrier-mediated dipeptide transport in kidney.

@article{Skopicki1996GentamicinIC,
  title={Gentamicin inhibits carrier-mediated dipeptide transport in kidney.},
  author={Hal A. Skopicki and Demetrios Zikos and Ernest J. Sukowski and K A Fisher and Darryl R. Peterson},
  journal={The American journal of physiology},
  year={1996},
  volume={270 3 Pt 2},
  pages={
          F531-8
        }
}
The effect of gentamicin on transport of pyroglutamylhistidine (pGlu-His) was examined in rabbit renal brush-border membrane vesicles (BBMV). Gentamicin, an aminoglycoside antibiotic, is limited in its usage because of nephrotoxicity characterized in part by transport defects in the proximal tubule. Since there is no information regarding the effects of gentamicin on renal peptide carriers, uptake of [3H]pGlu-His was measured in BBMV following either in vivo or in vitro exposure to the… 
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[ES] La gentamicina antibiotico aminoglucosido ampliamente utilizado en la practica clinica para el tratamiento de infecciones por microorganismos Gram negativos. Sin embargo, su uso esta limitado