Gentamicin effects on renal ischemia/reperfusion injury.

  title={Gentamicin effects on renal ischemia/reperfusion injury.},
  author={Richard A Zager},
  journal={Circulation research},
  volume={70 1},
This study assessed gentamicin's effects on ischemia/reperfusion renal injury to better understand when and how it worsens postischemic acute renal failure. Rats were subjected to 25 minutes of renal pedicle occlusion with and without preischemic (15-minute) or postischemic (15-minute or 8-hour) gentamicin treatment (100 mg/kg, by itself a subtoxic dose). Gentamicin's impact on hypoxia/reoxygenation injury to isolated rat proximal tubular segments was also assessed. Preischemic and postischemic… CONTINUE READING
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