Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results.

@article{Politano2003GentamicinAI,
  title={Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results.},
  author={Luisa Politano and Giovanni Nigro and Vincenzo Nigro and Giulio Piluso and Serenella Papparella and Orlando Paciello and Lucia I Comi},
  journal={Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology},
  year={2003},
  volume={22 1},
  pages={15-21}
}
Aim of the study was to investigate whether the administration of gentamicin could restore dystrophin expression in striated muscles of patients with Duchenne muscular dystrophy caused by premature stop codon, as reported in mdx mice. Four Duchenne patients, still ambulant or in wheelchair stage for less than 4 months, selected among those with point mutations resulting in premature stop codons, received two 6-day cycles of gentamicin sulfate, at an interval of 7 weeks, according to the… CONTINUE READING

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