Gentamicin administered during gestation alters glomerular basement membrane development.

@article{Smaoui1993GentamicinAD,
  title={Gentamicin administered during gestation alters glomerular basement membrane development.},
  author={Hatem Smaoui and Jean Pierre Malli{\'e} and Madeleine Schaeverbeke and Anne Robert and Jean Schaeverbeke},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 7},
  pages={
          1510-7
        }
}
Gentamicin during gestation alters glomerular basement membrane development. A drug-induced nephrotoxicity was described for neonates after gentamicin was given intraperitoneally to pregnant Wistar rats; glomerular alterations and changes in permselectivity were important. We investigated the ultrastructure of the glomerular basement membrane (GBM), the arrangement of anionic sites, and the urinary proteins at two ages, with 1-day- and 12-month-old control and prenatally exposed animals. For… CONTINUE READING

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