Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D.

@article{Wu1995GenotypingOH,
  title={Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D.},
  author={J C Wu and K B Choo and Chii Ming Chen and Zhen Chen and Teh-Ia Huo and S. D. Lee},
  journal={Lancet},
  year={1995},
  volume={346 8980},
  pages={939-41}
}
The outcome of hepatitis D virus (HDV) superinfection varies among patients and in different geographical areas. To find out whether HDV genotype affects outcome, we used a simple genotyping method based on restriction-fragment length polymorphism with enzymes XhoI and SacII for cleavage of PCR products of the HDV genome. Of samples from 88 patients studied, the genotypes of 61 were confirmed by two methods--analysis with both enzymes or by combined restriction-enzyme and direct sequencing… CONTINUE READING

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