Genotyping of -374A/T, -429A/G, and 63 bp Ins/del polymorphisms of RAGE by rapid one-step hexaprimer amplification refractory mutation system polymerase chain reaction in breast cancer patients.

@article{Hashemi2012GenotypingO,
  title={Genotyping of -374A/T, -429A/G, and 63 bp Ins/del polymorphisms of RAGE by rapid one-step hexaprimer amplification refractory mutation system polymerase chain reaction in breast cancer patients.},
  author={Mohammad Hashemi and Abdolkarim Moazeni-Roodi and Farshid Arbabi and Aliakbar Fazaeli and Ebrahim Eskandari Nasab and Mohsen Taheri and C van den Kerkhoff and Saeid Ghavami},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2012},
  volume={31 5},
  pages={401-10}
}
Several studies have focused on the RAGE genetic background and have demonstrated that its polymorphisms affect the receptor's activity, expression, and downstream signaling. However, there is only little information regarding RAGE polymorphism in breast cancer. In the present study, the authors studied RAGE polymorphisms in 71 patients with breast cancer and 93 healthy women. RAGE -374T/A, -429T/C, and 63 bp Ins/del polymorphisms were analyzed using a hexaprimer amplification refractory… CONTINUE READING

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Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42

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