Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma


PURPOSE Normal tension glaucoma (NTG) is a subtype of glaucoma in which intraocular pressure is within the statistically normal range. NTG may be associated with an immune disorder. The aim of this study was to determine whether specific alleles in the human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 genes correlated with NTG in Japanese patients. METHODS We genotyped the HLA-DRB1 and HLA-DQB1 alleles in 113 Japanese patients with NTG and in 184 healthy Japanese control subjects using the polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) Luminex method. We assessed the allelic diversity in patients and controls. RESULTS There were no statistically significant differences in the allele frequency of HLADRB1 and HLA-DQB1 between NTG patients and control subjects, and no HLA-DRB1-HLA-DQB1 haplotypes demonstrated any significant association with NTG. CONCLUSIONS Our findings suggest that HLA-DRB1 and HLA-DQB1 polymorphisms have no significant effect on the development of NTG in Japanese patients.

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@inproceedings{Suzuki2010GenotypingHA, title={Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma}, author={Misa Suzuki and Akira Meguro and Masao Ota and Eiichi Nomura and Tetsuo Kato and Naoko Nomura and Kenji Kashiwagi and Fumihiko Mabuchi and Hiroyuki Iijima and Kazuhide Kawase and Tetsuya Yamamoto and Makoto Nakamura and Akira Negi and Takeshi Sagara and Teruo Nishida and Masaru Inatani and Hidenobu Tanihara and Makoto Aihara and Makoto Araie and Takeo Fukuchi and Haruki Abe and Tomomi Higashide and Kazuhisa Sugiyama and Takashi Kanamoto and Yoshiaki Kiuchi and Aiko Iwase and Shigeaki Ohno and Hidetoshi Inoko and Nobuhisa Mizuki}, booktitle={Molecular vision}, year={2010} }