Genotypic testing for HIV-1 drug resistance using dried blood samples

@article{Lira2010GenotypicTF,
  title={Genotypic testing for HIV-1 drug resistance using dried blood samples},
  author={Rosalia Lira and Hilda-Alicia Valdez-Salazar and Guillermo Vazquez-Rosales and Oth{\'o}n Rojas-Montes and Martha-Eugenia Ruiz-Tachiqu{\'i}n and Rocio Torres-Ibarra and Carlos Cano-Dominguez and Ang{\'e}lica Maldonado-Rodr{\'i}guez and Alejandro Gomez and Oscar Dur{\'a}n Mu{\~n}oz and Ma-Teresa Alvarez-Mu{\~n}oz},
  journal={Archives of Virology},
  year={2010},
  volume={155},
  pages={1117-1125}
}
In third-world countries, dried blood samples (DBS) are a convenient alternative to plasma for monitoring viral load during HIV-1 therapy. In this study, we evaluated the feasibility of using DBS to perform HIV-1 drug resistance genotyping in a ViroSeq assay in which the protease and reverse transcriptase regions of the pol gene are analyzed. Fifty-seven antiretroviral genotypes from plasma samples were tested, and drug resistance genotypes were determined. Only 38.6% paired DBS samples were… CONTINUE READING
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