Genotypic resistance in Helicobacter pylori strains correlates with susceptibility test and treatment outcomes after levofloxacin- and clarithromycin-based therapies.

@article{Liou2011GenotypicRI,
  title={Genotypic resistance in Helicobacter pylori strains correlates with susceptibility test and treatment outcomes after levofloxacin- and clarithromycin-based therapies.},
  author={Jyh-Ming Liou and Chi-Yang Chang and Wang-Huei Sheng and Yu-chi Wang and Mei-Jyh Chen and Yi-Chia Lee and Hsu-Wei Hung and Hung Chian and San-Chun Chang and Ming-Shiang Wu and Jaw-town Lin},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 3},
  pages={
          1123-9
        }
}
The accuracy of genotypic resistance to levofloxacin (gyrA mutations) and its agreement with treatment outcomes after levofloxacin-based therapy have not been reported. We aimed to assess the correlation. Helicobacter pylori strains isolated from patients who received levofloxacin-based and clarithromycin-based triple therapies in a previous randomized trial were analyzed for point mutations in gyrA and 23S rRNA. PCR followed by direct sequencing was used to assess the gyrA and 23S rRNA… CONTINUE READING

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