Genotypic interactions of renin-angiotensin system genes in myocardial infarction.

  title={Genotypic interactions of renin-angiotensin system genes in myocardial infarction.},
  author={Messias Ant{\^o}nio de Ara{\'u}jo and Lu{\'i}z Ricardo Goulart and Elis{\^a}ngela Rosa Cordeiro and Renata R{\'i}spoli Gatti and Bruno Soares Menezes and Clauber Lourenço and Heyder Diniz Silva},
  journal={International journal of cardiology},
  volume={103 1},
BACKGROUND Three-gene interactions among the genetic polymorphisms of the renin-angiotensin system (RAS) associated with acute myocardial infarction (AMI) have not been examined in a single population. We hypothesized that all types of gene-to-gene associations may occur in AMI, but that some will have a higher risk, depending on the gene frequencies. METHODS Polymorphisms of the AGT (M235T), ACE (I/D) and AGTR1 (A1166C) genes in AMI patients and controls were analyzed using the polymerase… CONTINUE READING
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