Genotypic influences on striatal dopaminergic regulation in mice

  title={Genotypic influences on striatal dopaminergic regulation in mice},
  author={James A. Severson and Patrick K. Randall and Caleb E. Finch},
  journal={Brain Research},
Genotypic influences on dopaminergic-induced behaviors and striatal dopaminergic receptors were evaluated in CBA/J, C57BL/6J and BALB/cJ male mice. CBA/J mice were less behaviorally sensitive to apomorphine (stereotypic behavior) but more sensitive to haloperidol (catalepsy) than C57BL/6J and BALB/cJ mice. Striatal dopaminergic receptors, assayed by binding of [3H]spiroperidol (antagonist) and [3H]ADTN (agonist), were 50% fewer in CBA/J compared to BALB/cJ mice; C57BL/6J mice had low to… CONTINUE READING


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