Genotypic detection of acyclovir-resistant HSV-1: characterization of 67 ACV-sensitive and 14 ACV-resistant viruses.

@article{Frobert2008GenotypicDO,
  title={Genotypic detection of acyclovir-resistant HSV-1: characterization of 67 ACV-sensitive and 14 ACV-resistant viruses.},
  author={{\'E}milie Frobert and Jean-Claude Cortay and Tadamasa Ooka and Fatiha Najioullah and Danielle Thouvenot and Bruno Lina and Florence Morfin},
  journal={Antiviral research},
  year={2008},
  volume={79 1},
  pages={28-36}
}
Infections due to herpes simplex virus (HSV) resistant to acyclovir (ACV) represent an important clinical concern in immunocompromised patients. In order to switch promptly to an appropriate treatment, rapid viral susceptibility assays are required. We developed herein a genotyping analysis focusing on thymidine kinase gene (TK) mutations in order to detect acyclovir-resistant HSV in clinical specimens. A total of 85 HSV-1 positive specimens collected from 69 patients were analyzed. TK gene… CONTINUE READING

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