Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic

@inproceedings{Cotton2014GenotypicAF,
  title={Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic},
  author={Laura A. Cotton and Xiaomei Tallie Kuang and Anh Quynh Thi Le and Jonathan M. Carlson and Benjamin Chan and Denis R. Chopera and Chanson J. Brumme and Tristan J. Markle and Eric Martin and Aniqa Shahid and Gursev Anmole and Philip Mwimanzi and Pauline Nassab and Kali A. Penney and Manal A. Rahman and M.-J. Milloy and Martin T. Schechter and Martin Markowitz and Mary Carrington and Bruce D. Walker and Theresa Wagner and Susan P Buchbinder and Jonathan Fuchs and Beryl A Koblin and Kenneth H. Mayer and P. Richard Harrigan and Mark A Brockman and Art F. Y. Poon and Zabrina L. Brumme},
  booktitle={PLoS genetics},
  year={2014}
}
HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of this phenomenon in an immunogenetically diverse population, we genotypically and functionally compared… CONTINUE READING