Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.

@article{Zong2002GenotypicAA,
  title={Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.},
  author={Jianchao Zong and Dolores M Ciufo and Raphael P. Viscidi and Lee Alagiozoglou and Stephen K Tyring and Peter Rady and Jan Orenstein and W. M. O. Boto and Henry Kalumbuja and Nino Romano and Mads Melbye and Gyeong Hoon Kang and Chris H. Boshoff and Gary S. Hayward},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2002},
  volume={23 3},
  pages={119-48}
}
BACKGROUND The genomes of human Kaposi's sarcoma-associated herpesvirus (KSHV) display several levels of DNA sequence heterogeneity and subgrouping that show distinctive clustering patterns in related human populations. The four major subtype patterns for the hypervariable ORF-K1 protein correlate closely with the principal diasporas resulting from the migration of modern humans out of East Africa and suggest that KSHV is an ancient human virus that is transmitted primarily in a familial… CONTINUE READING