Genotypic Complexity of Fisher’s Geometric Model

@article{Hwang2017GenotypicCO,
  title={Genotypic Complexity of Fisher’s Geometric Model},
  author={Sungmin Hwang and Su-Chan Park and Joachim H A Krug},
  journal={Genetics},
  year={2017},
  volume={206},
  pages={1049 - 1079}
}
In his celebrated model of adaptation, Fisher assumed a smooth phenotype fitness map with one optimum. This assumption is at odds with the rugged..... Fisher’s geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from the nonlinear mapping of… 
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