Genotype-phenotype correlations: filling the void.

@article{Parsa2010GenotypephenotypeCF,
  title={Genotype-phenotype correlations: filling the void.},
  author={Afshin Parsa},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2010},
  volume={5 9},
  pages={1542-3}
}
C lassical Mendelian genetics often conjure the image of a well-defined mutation in the DNA sequence that causes a disruption in gene function and characteristic phenotype. However, Mendelian traits can often behave like complex disease traits. One level of complexity is that even a specific mutation may be associated with a wide spectrum of symptoms, with… CONTINUE READING