Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals

@article{Kayvanpour2016GenotypephenotypeAI,
  title={Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals},
  author={Elham Kayvanpour and Farbod Sedaghat-Hamedani and Ali Amr and Alan Lai and Jan Haas and Daniel Holzer and Karen S. Frese and Andreas Keller and Katrin Jensen and Hugo A. Katus and Benjamin Meder},
  journal={Clinical Research in Cardiology},
  year={2016},
  volume={106},
  pages={127-139}
}
AimsRoutine genetic testing in Dilated Cardiomyopathy (DCM) has recently become reality using Next-Generation Sequencing. [...] Key Method We summarized and extensively reviewed all studies that passed selection criteria and performed a meta-analysis on key phenotypic parameters. Together, 48 studies with 8097 patients were included. Furthermore, we reviewed recent studies investigating genotype-phenotype associations in DCM patients with TTN mutations. The average frequency of mutations in the investigated…Expand
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