Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder.

@article{Furmark2009GenotypeOI,
  title={Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder.},
  author={Tomas Furmark and Susanne Henningsson and Lieuwe Appel and Fredrik {\AA}hs and Clas Linnman and Anna Pissiota and Vanda Faria and Lars Oreland and Massimo Bani and Emilio Merlo Pich and Elias Eriksson and Mats Fredrikson},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={2009},
  volume={34 1},
  pages={30-40}
}
BACKGROUND Although the amygdala is thought to be a crucial brain region for negative affect, neuroimaging studies do not always show enhanced amygdala response to aversive stimuli in patients with anxiety disorders. Serotonin (5-HT)-related genotypes may contribute to interindividual variability in amygdala responsiveness. The short (s) allele of the 5-HT transporter linked polymorphic region (5-HTTLPR) and the T variant of the G-703T polymorphism in the tryptophan hydroxylase-2 (TPH2) gene… CONTINUE READING