Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis.

@article{Lio2002GenotypeFO,
  title={Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis.},
  author={Domenico Lio and Vincenzo Marino and Alberto Serauto and V. Gioia and Letizia Scola and Antonio Crivello and Giusi Irma Forte and Giuseppina Colonna-Romano and G Candore and Calogero Caruso},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  year={2002},
  volume={29 5},
  pages={371-4}
}
In the light of the key role played by interferon (IFN)-gamma in the control of tuberculosis, in the present paper we have evaluated the distribution of the functional +874T --> A IFN-gamma single nucleotide polymorphism (SNP) in Sicilian patients affected by tuberculosis. Our aim was to determine whether there is an association between the TT genotype, which has been suggested to be linked to an increased production of IFN-gamma, and resistance to chronic tuberculosis. DNA samples were… CONTINUE READING
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