Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

  title={Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.},
  author={Luigi Cervo and Alessandro Canetta and Eleonora Calcagno and Silvia Burbassi and Giuseppina Sacchetti and Silvio Caccia and Claudia Fracasso and Diego Albani and Gianluigi Forloni and Roberto William Invernizzi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 36},
Polymorphism of tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of brain serotonin (5-HT), is associated with less synthesis of brain 5-HT in DBA/2J and BALB/c than in C57BL/6J and 129/Sv mice. We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a selective 5-HT reuptake inhibitor. Citalopram reduced immobility time in C57BL/6J and 129… CONTINUE READING


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