Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

@article{Cervo2005GenotypedependentAO,
  title={Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.},
  author={Luigi Cervo and Alessandro Canetta and Eleonora Calcagno and Silvia Burbassi and Giuseppina Sacchetti and Silvio Caccia and Claudia Fracasso and Diego Albani and Gianluigi Forloni and Roberto William Invernizzi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 36},
  pages={8165-72}
}
Polymorphism of tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of brain serotonin (5-HT), is associated with less synthesis of brain 5-HT in DBA/2J and BALB/c than in C57BL/6J and 129/Sv mice. We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a selective 5-HT reuptake inhibitor. Citalopram reduced immobility time in C57BL/6J and 129… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 6 Excerpts
Highly Influenced

Citalopram: a comprehensive review.

Expert opinion on pharmacotherapy • 2001
View 1 Excerpt
Highly Influenced

Use of tryptophan in combination with other antidepressant treatments: a review.

Journal of psychiatry & neuroscience : JPN • 1991
View 15 Excerpts
Highly Influenced

Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain

Naunyn-Schmiedeberg's Archives of Pharmacology • 1978
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…