Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells

Abstract

Huntington’s Disease (HD) is caused by trinucleotide CAG repeat expansion >36 in huntingtin (htt), a protein with several documented functions. The elongated polyglutamine (polyQ) stretch in the N-terminal region of htt leads to dysfunctional and degenerative events in neurons and peripheral tissues. In this study, by extending the analysis to several… (More)
DOI: 10.1007/s00702-011-0646-1

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