Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547)

Abstract

Agent No. 547 (1,3-bis[ω-(diethyl-ortho-nitrobenzylammonio)-pentyl]-6-methyluracil dibromide), a newly synthesized inhibitor of mammalian-specific acetyltcholinesterase (EC 3.1.1.7) was investigated for genotoxicity using the DNA-repair test, Ames test and in vivo micronucleus test with mouse peripheral blood erythrocytes. Agent No. 547 did not cause… (More)
DOI: 10.1007/s00204-001-0302-x

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