Genotoxicity profiles of common alkyl halides and esters with alkylating activity.

@article{Sobol2007GenotoxicityPO,
  title={Genotoxicity profiles of common alkyl halides and esters with alkylating activity.},
  author={Zhanna Sobol and Maria E Engel and Elizabeth E Rubitski and Warren W. Ku and Jiri Aubrecht and Robert H. Schiestl},
  journal={Mutation research},
  year={2007},
  volume={633 2},
  pages={80-94}
}
Drug synthesis and/or formulation can generate genotoxic impurities. For instance, strong acid/alcohol interactions during the process of drug salt formation produce alkylating agents such as alkyl halides and alkyl esters of alkyl sulfonic acids. The genotoxicity of a few classic alkylating agents such as methyl and ethyl methanesulfonate have been previously well characterized, whereas the majority of compounds from this class have only been tested in the Salmonella reversion assay. Therefore… CONTINUE READING