Genotoxicity of stannous chloride in yeast and bacteria.

  title={Genotoxicity of stannous chloride in yeast and bacteria.},
  author={Cristina Pungartnik and Charles Viau and Jaqueline Nascimento Picada and A Caldeira-de-ara{\'u}jo and Jo{\~a}o Antonio P{\^e}gas Henriques and Martin Brendel},
  journal={Mutation research},
  volume={583 2},
Stannous chloride was found genotoxic in microbial test systems of the yeast Saccharomyces cerevisiae, in one strain of Salmonella typhimurium and in the Mutoxitest of Escherichia coli. Five isogenic haploid yeast strains differing only in a particular repair-deficiency had the following ranking in Sn2+ -sensitivity: rad52delta>rad6delta>rad2delta>rad4delta>RAD, indicating a higher relevance of recombinogenic repair mechanisms than nucleotide excision in repair of Sn2+ -induced DNA damage. Sn2… CONTINUE READING


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