Genotoxicity of poorly soluble particles.

  title={Genotoxicity of poorly soluble particles.},
  author={Roel P F Schins and Ad M. Knaapen},
  journal={Inhalation toxicology},
  volume={19 Suppl 1},
Poorly soluble particles such as TiO2, carbon black, and diesel exhaust particles have been evaluated for their genotoxicity using both in vitro and in vivo assays, since inhalation of these compounds by rats at high concentrations has been found to lead to tumor formation. Two principle modes of genotoxic action can be considered for particles, referred to as primary and secondary genotoxicity. Primary genotoxicity is defined as genetic damage elicited by particles in the absence of pulmonary… CONTINUE READING
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