Genotoxicity of inorganic lead salts and disturbance of microtubule function.

@article{Bonacker2005GenotoxicityOI,
  title={Genotoxicity of inorganic lead salts and disturbance of microtubule function.},
  author={Daniela Bonacker and Thomas R. Stoiber and Konrad Joachim B{\"o}hm and Irina Prots and Minsheng Wang and Eberhard Unger and Ricarda Thier and Hermann Maximillian Bolt and Gisela H. Degen},
  journal={Environmental and molecular mutagenesis},
  year={2005},
  volume={45 4},
  pages={
          346-53
        }
}
Lead compounds are known genotoxicants, principally affecting the integrity of chromosomes. Lead chloride and lead acetate induced concentration-dependent increases in micronucleus frequency in V79 cells, starting at 1.1 microM lead chloride and 0.05 microM lead acetate. The difference between the lead salts, which was expected based on their relative abilities to form complex acetato-cations, was confirmed in an independent experiment. CREST analyses of the micronuclei verified that lead… CONTINUE READING
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