Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo.

@article{Szyfter2004GenotoxicityOI,
  title={Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo.},
  author={Krzysztof Szyfter and Roman Szulc and Adam Mikstacki and Ireneusz Stachecki and Małgorzata Rydzanicz and Piotr Jałoszyński},
  journal={Journal of applied genetics},
  year={2004},
  volume={45 3},
  pages={369-74}
}
A moderate genotoxic activity of halothane and isoflurane applied as volatile anaesthetics has already been shown. The aim of this work was to estimate a potential genotoxicity of sevoflurane, introduced to clinical practice later than halothane and isoflurane. A genotoxic activity of all three compounds was estimated by using the comet assay in human peripheral blood lymphocytes (PBL) proliferating in vitro. We demonstrated that in contrast to the previously studied anaesthetics, sevoflurane… CONTINUE READING

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