Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.

  title={Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.},
  author={R C Grafstrom and Rodger D. Curren and Ling Yang and Curtis C. Harris},
  volume={228 4695},
Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.