Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence.

@article{Kalfalah2011GenotoxicityOD,
  title={Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence.},
  author={Faiza M Kalfalah and Christian Mielke and Morten O. Christensen and Simone A Baechler and Doris Marko and Fritz Boege},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 Suppl 1},
  pages={
          S127-42
        }
}
SCOPE DNA damage by genistein and etoposide is determined by the half-life of topoisomerase II-DNA linkage induced [Bandele O. J. and Osheroff N., Biochemistry 2008, 47, 11900]. Here, we test whether this applies generally to dietary flavonoids and therapeutic compounds enhancing topoisomerase II-DNA cleavage (Topo II poisons). METHODS AND RESULTS We compared the impact of Topo II poisons on DNA residence kinetics of biofluorescent human topoisomerases IIα and IIβ (delineating duration of the… CONTINUE READING
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