Genotoxicity of carcinogens in human hepatocytes: application in hazard assessment.

@article{Mcqueen1988GenotoxicityOC,
  title={Genotoxicity of carcinogens in human hepatocytes: application in hazard assessment.},
  author={Charlene A. Mcqueen and B M Way and G. M. Williams},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={96 2},
  pages={
          360-6
        }
}
DNA-Reactive Carcinogens: Mode of Action and Human Cancer Hazard
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A set of key events whereby DNA reactivity initiates the process of carcinogenicity that leads to the subsequent mutation induction and enhanced cell proliferation that ultimately results in tumor development is presented.
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An integrated strategy, that includes the use of human-based cells with enhanced biological relevance and throughput, and applying the quantitative analysis of data, may provide an approach for future genotoxicity risk assessment.
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TLDR
The basis for distinguishing between carcinogens that have either DNA reactivity or an epigenetic activity as their primary mechanism of action is detailed in this review.
Carcinogen metabolism in cultured human tissues and cells.
TLDR
Construction of cell lines, expressing the human forms of the carcinogen metabolizing enzymes, by biotechnology provides a new model to study the metabolism and to monitor for genetic markers in the same cells.
Chemical carcinogen mechanisms of action and implications for testing methodology.
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The results demonstrate that hepatocytes can be used to assess genotoxicity of carcinogenic compounds and are useful for interspecies comparisons in chemical carcinogenesis.
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