Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.

@article{Kotova2013GenotoxicityOA,
  title={Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.},
  author={Natalia Kotova and Daniel Vare and Niklas Schultz and Dobroslawa Gradecka Meesters and Maciej Stępnik and Jan Graw{\'e} and Thomas Helleday and Dag Jenssen},
  journal={Carcinogenesis},
  year={2013},
  volume={34 2},
  pages={
          325-30
        }
}
Although alcohol consumption is related to increased cancer risk, its molecular mechanism remains unclear. Here, we demonstrate that an intake of 10% alcohol for 4 weeks in rats is genotoxic due to induction of micronuclei. Acetaldehyde (AA), the first product of ethanol metabolism, is believed to be responsible for DNA damage induced by alcohol. Here, we observe that AA effectively blocks DNA replication elongation in mammalian cells, resulting in DNA double-strand breaks associated with… CONTINUE READING
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