Genotoxicity of acute and chronic gamma-irradiation on zebrafish cells and consequences for embryo development.

@article{Pereira2011GenotoxicityOA,
  title={Genotoxicity of acute and chronic gamma-irradiation on zebrafish cells and consequences for embryo development.},
  author={Sandrine Pereira and St{\'e}phanie Bourrachot and Isabelle Cavali{\'e} and Delphine Plaire and Morgan Dutilleul and Rodolphe Gilbin and Christelle Adam-Guillermin},
  journal={Environmental toxicology and chemistry},
  year={2011},
  volume={30 12},
  pages={2831-7}
}
The effects of radiation on biological systems have been studied for many years, and it is now accepted that direct damage to DNA from radiation is the triggering event leading to biological effects. In the present study, DNA damage induced by acute or chronic irradiation was compared at the cellular (zebrafish [Danio rerio] cell line ZF4) and developmental (embryo) levels. Zebrafish ZF4 cells and embryos (at 3 h postfertilization) were exposed within ranges of acute doses (0.3-2 Gy/d) or… CONTINUE READING