Genotoxicity of acrylic bone cements.

  title={Genotoxicity of acrylic bone cements.},
  author={J\orgen S. Jensen and Annette Sylvest and B Trap and J\orn Jensen},
  journal={Pharmacology & toxicology},
  volume={69 5},
The genotoxicity of conventional polymethylmethacrylate (PMMA) and a new formulation of bone cement: methylmethacrylate/n-decylmethacrylate/isobornylmethacrylate (MMA/DMA/IBMA) were tested by micronucleus test and reverse mutation assays of Salmonella typhimurium (Ames test). In extracts from cement pellets (37 degrees, 72 hr) with water and water/ethanol the concentration of MMA was reduced by 13-19 times with the new formulation and the concentrations of accelerators were reduced by 4-5 times… CONTINUE READING