Genotoxicity of 1,1-dichloroethane.


1,1-Dichloroethane is covalently bound to macromolecules of rat and mouse organs in vivo after ip injection. Covalent Binding Index is typical of initiators classified as weak carcinogens. In vitro binding of 1,1-dichloroethane to nucleic acids and proteins is mediated by liver P-450-dependent microsomal mixed function oxidase system. Lung microsomes are… (More)


Cite this paper

@article{Colacci1985GenotoxicityO1, title={Genotoxicity of 1,1-dichloroethane.}, author={Anna Maria Colacci and Giancarlo Arfellini and Mario Mazzullo and Giorgio Prodi and Sandro Grilli}, journal={Research communications in chemical pathology and pharmacology}, year={1985}, volume={49 2}, pages={243-54} }