Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model

  title={Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model},
  author={Brian Ogushi Silva and Juliana Botinhon Orlando and Camila Lehnhardt Pires and Cl{\'e}lia Akiko Hiruma-Lima and Isabel O'Neill de Mascarenhas Gaiv{\~a}o and F{\'a}bio F. Perazzo and Edson Luis Maistro},
  journal={Journal of Toxicology and Environmental Health, Part A},
  pages={518 - 528}
ABSTRACT Nerol (cis-3,7-dimethyl-2,6-octadien-1-ol) is a monoterpene widely used in cosmetic products, household detergents and cleaners, as well as a flavoring in several food products. Despite the high level of human exposure to nerol, an absence of studies regarding potential genetic toxicity in human cells exists. The aim of this investigation was to examine the cytotoxic and genotoxic potential of this monoterpene on human peripheral blood mononuclear cells as well as hepatic metabolizing… 
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Under experimental conditions, caution is recommended in the use of beta-myrcene, since this compound produced genotoxic effects especially after metabolic activation using human HepG2/C3A cells, which may be associated with carcinogenic and teratogenic effects previously reported in the literature.
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This oregano essential oil appears to be safe in Wistar rats and might be considered as a potential active material in food packaging industry.
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The genotoxic activity of 15 essential oil constituents used as flavouring agents or cosmetic ingredients was assessed at four concentrations (2.5, 5.0, 7.5 and 10 µl/ml) using the Drosophila
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Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential
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