Corpus ID: 40666197

Genotoxicity assessment using micronuclei assay in rheumatoid arthritis patients.

  title={Genotoxicity assessment using micronuclei assay in rheumatoid arthritis patients.},
  author={C. Ramos-Remus and G. Dorazco-Barragan and F. Aceves-{\'A}vila and F. Alcaraz-Lopez and F. Fuentes-Ramirez and J. Michel-Diaz and O. Torres-Bugar{\'i}n and A. Ventura-Aguilar and G. Z{\'u}{\~n}iga-Gonz{\'a}lez},
  journal={Clinical and experimental rheumatology},
  volume={20 2},
  • C. Ramos-Remus, G. Dorazco-Barragan, +6 authors G. Zúñiga-González
  • Published 2002
  • Medicine
  • Clinical and experimental rheumatology
  • OBJECTIVES This study investigated whether: (i) rheumatoid arthritis (RA) patients have more micronuclei (MN) than healthy controls; (ii) methotrexate (MTX) treated RA patients have more MN than those not using MTX, and (iii) folic acid supplementation decreases the number of MN in MTX treated patients. METHODS MN assays were performed in oral mucosa sweeps of 50 consecutive MTX treated RA patients, 30 consecutive RA patients not receiving MTX and 39 healthy controls. MTX treated RA patients… CONTINUE READING

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