Genotoxicity and oxidative stress induced by pesticide exposure in bovine lymphocyte cultures in vitro.

@article{Lioi1998GenotoxicityAO,
  title={Genotoxicity and oxidative stress induced by pesticide exposure in bovine lymphocyte cultures in vitro.},
  author={Maria Brigida Lioi and Maria Rosaria Scarfi and Antonietta Santoro and Rocchina Barbieri and Olga Zeni and Dino Di Berardino and Matilde Valeria Ursini},
  journal={Mutation research},
  year={1998},
  volume={403 1-2},
  pages={13-20}
}
The genotoxic activity of the pesticides gliphosate, vinclozolin and DPX-E9636 was studied in in vitro cultures of bovine lymphocytes, using chromosome aberration (CA) and sister chromatid exchange (SCE) frequencies as genetic end-points and a variation of glucose 6-phosphate dehydrogenase (G6PD) enzyme activity as a marker of changes in the normal cell redox state. Results indicated a statistically significant increase of structural aberrations, sister chromatid exchanges and G6PD activity… CONTINUE READING
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