Genotoxicity and immunogenicity of DNA-advanced glycation end products formed by methylglyoxal and lysine in presence of Cu2+.

@article{Ahmad2011GenotoxicityAI,
  title={Genotoxicity and immunogenicity of DNA-advanced glycation end products formed by methylglyoxal and lysine in presence of Cu2+.},
  author={Saheem Ahmad and Moinuddin and Kiran Dixit and Uzma Shahab and Khursheed Alam and Asif Ali},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={407 3},
  pages={
          568-74
        }
}
The highly reactive electrophile, methylglyoxal (MG), a break down product of carbohydrates, is a major environmental mutagen having potential genotoxic effects. Previous studies have suggested the reaction of MG with free amino groups of proteins forming advanced glycation end products (AGEs). This results in the generation of free radicals which play an important role in pathophysiology of aging and diabetic complications. MG also reacts with free amino group of nucleic acids resulting in the… CONTINUE READING
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