Genotoxicity and fetal abnormality in streptozotocin-induced diabetic rats exposed to cigarette smoke prior to and during pregnancy.

@article{Damasceno2011GenotoxicityAF,
  title={Genotoxicity and fetal abnormality in streptozotocin-induced diabetic rats exposed to cigarette smoke prior to and during pregnancy.},
  author={D{\'e}bora Cristina Damasceno and Gustavo Tadeu Volpato and Yuri Karen Sinzato and Paula Helena Ortiz Lima and Martina Schaan de Souza and Isabela Lovizutto Iessi and Ana Carolina Inhasz Kiss and Mariana Takaku and Marilza Vieira Cunha Rudge and Iracema M P Calder{\'o}n},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2011},
  volume={119 9},
  pages={
          549-53
        }
}
BACKGROUND Maternal hyperglycemia during early pregnancy is associated with increased risk of abnormalities in the offspring. Malformation rates among the offspring of diabetic mothers are 2-5-fold higher than that of the normal population, and congenital malformations are the major cause of mortality and morbidity in the offspring of diabetic mothers. Metabolic changes, such as hyperglycemia and the metabolites obtained from cigarettes both increase the production of reactive oxygen species… CONTINUE READING
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