Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals.

@article{Griffin1986GenotoxicityAC,
  title={Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals.},
  author={Donna S. Griffin and Henry J Segall},
  journal={Toxicology and applied pharmacology},
  year={1986},
  volume={86 2},
  pages={227-34}
}
Recently our laboratory isolated trans-4-OH-2-hexenal from the hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid (PA) senecionine and demonstrated in vivo that hepatic necrosis occurred following injection into the hepatic portal vein. To demonstrate similarities in the toxic effects of these compounds, as well as additional macrocyclic PAs and alkenals, genotoxicity and cytotoxicity were examined in primary cultures of rat hepatocytes. A positive cytotoxic response was… CONTINUE READING

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